BioRxiv (2023) PubMed PMID: 37546940; PubMed Central PMCID: PMC10402079.. Abstract. The mammalian innate immune system uses cyclic GMP–AMP synthase (cGAS) to synthesize the cyclic dinucleotide ...

In all organisms, innate immune pathways sense infection and rapidly activate potent immune responses while avoiding inappropriate activation (autoimmunity). In humans, the innate immune receptor ...

In humans, the innate immune receptor cGAS detects viral infection to produce the nucleotide second messenger cGAMP, which initiates STING-dependent antiviral signaling. Bacteria encode predecessors ...

This small molecule is a potent and selective PDE-1 phosphodiesterase inhibitor that increases neuronal levels of cyclic nucleotide second messengers. Lu AF88434 is intended to enhance neuroplasticity ...

Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, ... Intriguingly, some mRNAs acquire an additional methylation at their second nucleotide.