Although a crystal structure of filamentous actin (F-actin ... so crucial in models of myosin function, also need to be understood. Extensive mutational analysis will help answer these and ...

(In nonmuscle cells, actin filaments are less organized and myosin is much less prominent ... but they are generally strong and ropelike. Their functions are primarily mechanical and, as a ...

Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions ...

In this article, we discuss the structure and function of cardiac muscle tissue ... due to alternating filaments that comprise myosin and actin proteins. The dark stripes indicate thick filaments ...

Sarcomeric myosin heavy chain proteins are the molecular motors responsible for muscle contraction. Mutations in these proteins perturb their interactions with other proteins and their function, which ...