Scientists from Johns Hopkins Medicine and eight other institutions in the United States, Africa and Europe say they have ...

View Full Profile. Learn about our Editorial Policies. Today, the cause of sickle cell disease is well understood to be a point mutation in a hemoglobin gene called HBB that makes red blood cells grow ...

Sickle Cell Disease is a complex and debilitating genetic ... It is caused by a mutation in the HBB gene, which leads to the production of abnormal haemoglobin known as haemoglobin S.

Sickle cell disease (SCD) is an autosomal recessive blood disorder characterized by the presence of abnormal adult hemoglobin in red blood cells (RBCs). These erythrocytes become dehydrated ...

The evolutionary link between sickle-cell trait and malaria resistance showed ... In this way, they can identify genetic variants conferring resistance to infectious diseases that have spread ...