Based on studies of Trulance and Linzess, neither drug is known to interact with other medications. But it’s possible that interactions for either medication could be discovered in the future.

The drug may be entirely different since there’s no generic version of Linzess. Common alternatives to Linzess include plecanatide (Trulance), lubiprostone (Amitiza), tegaserod (Zelnorm), and ...

1. Ironwood and Allergan partnered to develop and sell Linzess, a chronic idiopathic constipation and irritable bowel syndrome with constipation drug. Linzess has been on the market since 2012, ...