While humans exploit the venom as a psychedelic, it can cause irritation of the eyes and mouth of humans. Possession of the toad's venom is illegal in California, according to the zoo.

Evidently, toad venom contains other molecules besides 5-MeO-DMT, including a drug called bufotenine (5-HO-DMT), which also has some psychoactive effects, but are far less intense.

“Toad medicine is watching the movie in 3-D,” added Dr. Sandoval, who owns a ranch in Sonora, where he raises the toads and charges $500 for a venom ceremony.

Psychedelics & Environmental Protection: Company Seeks Patents To Synthetically Produce Toad Venom by Lara Goldstein, Benzinga Staff Writer December 12, 2022 1:56 PM | 2 min read | Make a Comment ...

Psychedelic toad venom, also known as 5-MeO-DMT, is a potent hallucinogen derived from the Colorado River toad. When vaporized and inhaled, it can lead to powerful, albeit short-lived, psychedelic ...

They compared it to LSD as well as existing drugs that target 5-HT 1A, and found that the toad venom compound had a similar antidepressant and anti-anxiety effect – without getting the mice high.

Why Is Everyone Smoking Toad Venom? How an illegal amphibian-venom-derived psychedelic became the loudest whisper at a dinner party near you. By Alex Kuczynski Published: Jan 20, 2022 9:00 AM EST ...

Toad-stones “touching any part envenomed by the bite of a rat, wasp, spider or other venomous beast, ceases the pain and swelling thereof.” This hermetic treatment seems to have had some value.

Previously HGTV's Christina Hall admitted to smoking the toad's venom to reduce anxiety. "Smoking the bufo toad venom is a life-changing experience and different for every person.

The National Park Service has put out a PSA pleading with nature-goers to stop licking toads in the wild amidst travelers getting high off their gland-secreted psychedelic substance, 5-MeO-DMT.