“Succinate is not a compound that people can now take as a treatment, but it’s proof-of-principle that you can re-energize the Krebs cycle,” explained Dr. Stuart Lipton, senior author of the ...

One key discovery was a bottleneck in the Krebs cycle, specifically in the production of succinate, a molecule crucial for generating ATP—the primary energy source of cells.

"Succinate is not a compound that people can now take as a treatment, but it's proof-of-principle that you can re-energize the Krebs cycle," says Lipton.