Norman Osborn - the Green Goblin - was gone, his best friend was fatherless, Uncle Ben did what all Uncle Ben's do, etc.. It was all very sad. In Spider-Man 2, we see a Spider-Man without his powers.

Sam Raimi's Spider-Man 4 is one of the great "what-ifs?" in superhero/comic book movie history. Tobey Maguire and Kirsten Dunst never got their swan song in the roles of Peter Parker and Mary Jane ...

However, Spider-Man has lost his fair share of loved ones in the line of duty, from Gwen Stacy to Uncle Ben. Compound that with having to feel hundreds and hundreds of deaths over and over again ...