Pediatric Research - Toll-like receptors, the NLRP3 inflammasome, ... the mechanisms by which this single-nucleotide polymorphism, rs10754558, affects NLRP3 function are unknown.

The paper reports a new version of the Cardean CRISPR-Chip called SNP-Chip that can rapidly detect and quantify single nucleotide polymorphisms (SNPs), or point mutations, in unamplified, genomic ...

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease. Nature Medicine , 2015; DOI: 10.1038/nm.3804 Cite This Page : ...

The BioAge family of NLRP3 inhibitors has differentiated features including Unique and novel chemical structures and biological properties Drug-like metabolic stability and potent in vivo activity ...