Discover the current pipeline candidates advancing through the clinic for the treatment of sickle cell disease.

For people with SCD, hemoglobin S (a mutated protein that transports oxygen) causes red blood cells to become curved (sickle-shaped) and stiff. This disrupts how easily red blood cells and the oxygen ...

Most people with sickle cell disease produce an atypical form called hemoglobin S (HbS) instead. People with HbSS have one abnormal gene from each parent that codes for HbS. Hemoglobin SC (HbSC) ...

Hemoglobin S–beta-thalassemia: When individuals are diagnosed with this form of sickle cell disease, they inherit one sickle cell gene from one parent and one gene for beta thalassemia from ...

Sickle Cell Pain Tied to Hemoglobin In Blood. ... from malformed red blood cells of the vital protein that carries oxygen and episodes of severe pain in people with sickle cell disease. ...

September is Sickle Cell Awareness Month. One woman who suffers from the disease said there is a critical need for blood, especially from African Americans."It's really hard to deal with this ...

Gene editing could be a game changer for patients with sickle cell disease 05:36. The U.S. Food and Drug Administration on Friday approved a landmark gene-editing treatment for sickle cell disease ...

The Food and Drug Administration has granted Orphan Drug designation to KIND Pharmaceutical’s AND017 for the treatment of sickle cell disease (SCD). AND017 is an investigational oral hypoxia ...

The underutilization of disease-modifying therapy by people with sickle cell disease is “persistent and alarming,” according to an analysis of real-world data.The findings, presented in ...

PGC-1α agonism induces fetal hemoglobin and exerts antisickling effects in sickle cell disease. Science Advances , 2024; 10 (31) DOI: 10.1126/sciadv.adn8750 Cite This Page : ...

WASHINGTON — The only cure for painful sickle cell disease today is a bone marrow transplant. But soon there may be a new cure that attacks the disorder at its genetic source. On Tuesday ...

The FDA's approval of two new treatments for sickle cell disease could benefit patients in South Carolina. How many patients? SCDHEC is trying to find out.