“RNA can fold into well-defined tertiary structures with specialized functions,” said Peixuan Guo, Ph.D., who holds the William Farish Endowed Chair of Nanobiotechnology at the University of ...

Once the RNA is formed, like proteins it requires to undergo changes to form a specific tertiary structure. The scaffold for this structure is provided by secondary structural elements which are ...

Watson-Crick pairs form the double-stranded hairpins of RNA secondary structure. The remaining families are involved in the formation of RNA modules—the building blocks of tertiary structure ...

An approach taken from protein structure prediction makes it possible to computationally identify secondary and tertiary contacts in RNA.

The prediction for the RNA secondary structure was implemented as a binary quadratic model (BQM)on a D-wave quantum annealer (QA) with a Hamiltonian designed to optimize the number of non ...

RNA modifications play crucial roles in gene regulation, cellular function and the response to environmental stimuli. However, the detection and characterization of these modifications remain ...

To address this relationship between structure and function, structural biology makes use of some fundamental concepts related to the hierarchical assembly of proteins and nucleic acids (such as ...

Magnesium Contact Ions Stabilize the Tertiary Structure of Transfer RNA: Electrostatics Mapped by Two-Dimensional Infrared Spectra and Theoretical Simulations. The Journal of Physical Chemistry B ...

Deep learning is solving biology’s deepest secrets at breathtaking speed. Just a month ago, DeepMind cracked a 50-year-old grand challenge: protein folding. A week later, they produced a totally ...

The key innovation lies in introducing a deep learning approach for predicting RNA tertiary structure. While traditional methods relied on homologous modelling or physics-based folding simulations, ...