(New York, NY) for ompenaclid (RGX-202), a first-in-class oral inhibitor of the creatine transport channel SLC6A8, and SLC6A8-targeting follow-on compounds.

Isabel Kurth et al. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Science Advances , 2021 DOI: 10.1126/sciadv ...

Creatine Transporter Deficiency (CTD) is a rare, X‐linked metabolic disorder arising from mutations in the SLC6A8 gene, which encodes the creatine transporter protein. This condition disrupts ...

In a poster presentation today at the 2018 American Association of Cancer Research Annual Meeting, “RGX-202, a first-in-class small-molecule inhibitor of the creatine transporter SLC6a8, is a ...

Cerebral creatine (Cr) deficiency syndromes are caused by AGAT, GAMT or SLC6A8 deficiencies that may cause severe neurodevelopmental delay and intellectual disability. Novel AAV-based approach to ...

He was later diagnosed with a very rare genetic disorder called CTD, which stands for Creatine Transporter Deficiency which is mutations in the SLC6A8 gene. Now Kelly is speaking out ahead of Rare ...