aptamer domain (red), switching sequence (purple), and expression platform (blue). RNA is able to control its own transcription, given the right trigger. See how the RNA-based riboswitch twists ...

RNA is able to control its own transcription, given the right trigger. See how the RNA-based riboswitch twists into a tangle in the presence of the right ligand.

Cell-free systems, which can express an easily detectable protein with a DNA or mRNA template without constraints of living ...

This was first demonstrated in vitro and in vivo using the example of an RNA riboswitch. The versatility of the approach is highlighted by the first covalent "fluorescent light-up RNA aptamer ...