Remdesivir has been shown to target both RNA-dependent RNA polymerase and main protease of SARS-CoV-2 – resulting in a ‘double whammy’ effect.

Although the code Gilead assigned to the compound – GS-5734 – does not appear in the body of the application, experts who have reviewed the chemical structure say the compound is remdesivir.

Understanding this structure and the molecular details of how ExoN works can help guide further development of antivirals,” said Yang ... it could allow for the optimization of current antivirals, ...

The US Food and Drug Administration announced Monday that it has expanded approval of the Covid-19 drug remdesivir to treat patients as young as 28 days and weighing about 7 pounds.

The claims of this application plainly encompass a molecule with a structure that is now called remdesivir. Not long after ... small molecule GS-5734,” that was a victory for both public science ...

Remdesivir works by disrupting SARS-CoV-2's RNA polymerase, a key enzyme that the virus needs to replicate itself. When this enzyme is disrupted, the virus cannot multiply and spread within the body.

The drug is called Veklury, although most people refer to it by its scientific name, remdesivir. ... Of course, one would need the hardware to recreate the almost 400-atom molecule formula.

New PME research shows how the COVID-19 drug remdesivir works at the molecular level, which could help scientists determine how best to use it to treat the disease.

Their study reports the cryo-EM structure of the SARS-CoV-2 replicase both in the apo form at 2.8 Å resolution and in complex with a template-primer RNA and Remdesivir at 2.5 Å resolution.

Remdesivir does not reduce deaths among COVID-19 patients, as compared with standard care, ... an antiviral called lopinavir and an immune-stimulating molecule called Interferon-β1a.

In the treatment of COVID-19, antiviral drug remdesivir has emerged as a promising candidate. Remdesivir works by disrupting the virus’s ability to replicate, but its exact mechanism has remained a ...