In this phase 3, double-blind, randomized, placebo-controlled trial, we used a 2-by-3 factorial design to test the effectiveness of three repurposed drugs — metformin, ivermectin, and ...

Over 13 weeks, HbA1c decreased to 7.3% (±0.9) in the AID group and 7.7% (±1.1) in the control group. A difference of –0.6 percentage points was observed between the groups.

The primary efficacy outcome among the 550 participants with initially uncontrolled asthma showed significantly better ...

ZMapp was chosen as the control on the basis of data from the Partnership for Research on Ebola Virus in Liberia II (PREVAIL II) trial. 11 The current trial was originally designed in November ...

One hundred twenty-one consecutive patients with neuropathic pain due to cancer, partially controlled with systemic opioids, participated in a multicenter, randomized, double-blind, placebo-controlled ...

Fortunately, when randomized controlled trials are feasible and ethical, they provide a way to determine the effect of a program free from concerns about regression to the mean and other biases.

Other studies, including at least one with a non-randomized control group, suggested large reductions in emergency and hospital care after hot-spotting.