In this phase 3, double-blind, randomized, placebo-controlled trial, we used a 2-by-3 factorial design to test the effectiveness of three repurposed drugs — metformin, ivermectin, and ...

Over 13 weeks, HbA1c decreased to 7.3% (±0.9) in the AID group and 7.7% (±1.1) in the control group. A difference of –0.6 percentage points was observed between the groups.

The primary efficacy outcome among the 550 participants with initially uncontrolled asthma showed significantly better ...

ZMapp was chosen as the control on the basis of data from the Partnership for Research on Ebola Virus in Liberia II (PREVAIL II) trial. 11 The current trial was originally designed in November ...

Postoperative penile hypoxia is one potential contributor, Pedersen and co-authors noted. The rationale for LI-SWT to treat ...

The primary end point was objective response rate (ORR) according to RECIST (version 1.1). The experimental arm (modified FOLFOXIRI [mFOLFOXIRI] plus panitumumab) was considered active if the ORR was ...

Music therapy plus standard analgesia vs standard care alone reduced pain and anxiety in patients with nontrauma-related pain in the emergency department.

Fortunately, when randomized controlled trials are feasible and ethical, they provide a way to determine the effect of a program free from concerns about regression to the mean and other biases.