Randomized controlled trials (RCTs) are considered the gold-standard study design for comparative effectiveness research, which involves directly comparing the effectiveness of one treatment to ...

This section reviews a Bayesian design for a randomized comparative group sequential trial to compare nutritional prehabilitation (N) with standard of care (C) for patients with esophageal cancer ...

A randomized double-blind, comparative study of ARN-509 plus androgen deprivation therapy ... Approximately 1200 pts will be randomized to provide appropriate statistical rigor to detect the ...

The FOCUS study was initially designed and conducted as a randomized controlled trial but was amended to a single-arm design. As a result, comparative efficacy analyses were designated as exploratory.

However, “[this] randomized trial has generated more debate over its design and results than any in recent memory,” write Drs Peter Berger and James Blankenship, who were not involved in the ...

The FOCUS study was initially designed and conducted as a randomized controlled trial but was amended to a single-arm design. As a result, comparative efficacy analyses were designated as exploratory.