Novel mechanism eliminates 'bad' enzyme during gene expression
Northwestern Medicine investigators have discovered a novel mechanism that recognizes and eliminates "bad" transcriptional ...
How a multitasking protein keeps the body's clock in sync
If your genes could set an alarm clock, EZH1 might be the one ringing the bell. A new study has revealed how this ...
This Little-Known Protein Helps Your Body Stay in Sync – Here’s How
EZH1 is a key regulator of circadian rhythms, stabilizing gene transcription and modifying chromatin to maintain genetic ...
Howard Hughes Medical Institute2mon
A Portrait of RNA Polymerase
There are a variety of different types of RNA polymerases that can transcribe different types of RNA. RNA polymerase II, shown here, is responsible for creating messenger RNA (mRNA), which is the main ...
Nature1mon
Transcriptional noise and the fidelity of initiation by RNA polymerase II
Eukaryotes transcribe much of their genomes, but little is known about the fidelity of transcriptional initiation by RNA polymerase II in vivo.I suggest that ∼ 90% of Pol II initiation events in ...
Nature2y
RNA Transcription by RNA Polymerase: Prokaryotes vs Eukaryotes
This polymerase contains four catalytic subunits ... RNA pol I transcribes ribosomal RNAs (rRNAs), RNA pol II transcribes RNAs that will become messenger RNAs (mRNAs) and also small regulatory ...
Too Old to Operate6d
Nuclear ANLN regulates transcription initiation related Pol II clustering and target gene expression.
Anillin (ANLN), a mitotic protein that regulates contractile ring assembly, has been reported as an oncoprotein. However, the function of ANLN in cancer cells, especially in the nucleus, has not been ...
Helsinki3y
Center for Gene Regulation
Our mission is to elucidate fundamental mechanisms that control the elongation phase of transcription by RNA polymerase II (Pol II) in normal and disease states. We are particularly interested in ...