Researchers at the Johns Hopkins Kimmel Cancer Center and Department of Radiation Oncology and Molecular Radiation Sciences uncovered a new tumor-suppressive response that could lead to novel ...

A new study reveals that blocking ribosomal RNA production rewires cancer cell behavior and could help treat genetically ...

The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...

Role of RNA polymerase in gene transcription demonstrated Date: July 19, 2010 Source: University of Maryland Summary: Biophysicists have provided new insight into the mechanisms of gene transcription.

RNA polymerase in action. The three stages of transcription involve various functions of RNA polymerase that result in the synthesis of RNA: 1. Initiation begins when RNA polymerase wraps around the ...

Here, a cross-chiral RNA polymerase is developed—an RNA enzyme that can catalyse the templated polymerization of activated mononucleotides that are of the opposite handedness—shedding light on ...

The 1.9 Å resolution crystal structure of hepatitis C virus (HCV) nonstructural protein 5B (NS5B) presented here provides the first complete and detailed view of an RNA-dependent RNA polymerase.

Laiho holds patents on RNA polymerase 1 inhibitors, which are managed by The Johns Hopkins University in accordance with its conflict-of-interest policies. Journal. Cell Chemical Biology.

The RNA polymerase has two regions in which the lysine residues are arranged in a line. They found that these lysine residues correspond to two of the three paths.

What am I looking at? This is a 3D rendering of an RNA polymerase II enzyme from baker’s yeast, created using actual molecular data to reconstruct its shape and active sites. What looks like a ...

The researchers found that using a drug to inhibit RNA Polymerase 1 (Pol 1) - the enzyme responsible for human ribosomal RNA (rRNA) transcription - triggered a unique stress response that rewires ...

RNA polymerase in action. The three stages of transcription involve various functions of RNA polymerase that result in the synthesis of RNA: 1. Initiation begins when RNA polymerase wraps around the ...