By synchronizing the emission spectrum change of the fluorescent timer protein with provirus expression, HIV-Tocky enables precise tracking of provirus temporal dynamics from expression to silence.

Researchers have succeeded in developing a designer recombinase (Brec1) that is capable of specifically removing the provirus from infected cells of most primary HIV-1 isolates.

Viruses insert their genomes into their hosts in the form of a provirus. There are around 30 different kinds of human endogenous retroviruses in people today, amounting to over 60,000 proviruses in ...

Scientists have found that the HIV DNA -- or "provirus" -- inside resting cells is usually so defective that it cannot generate new virus particles.

The human ERV-K exists in the provirus form in the human genome, comprising sequences encoding proteins critical for the reactivation, and RVLP (retrovirus-like particle) formation, having ...

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nature Biotechnology 2016 Feb 22, advance online publication. doi: 10.1038/nbt.3467.