Leveraging fluorescent timer protein technology, HIV-Tocky features dual fluorescence, shifting from blue to red, to illuminate the process of provirus silencing and reactivation.

Researchers have succeeded in developing a designer recombinase (Brec1) that is capable of specifically removing the provirus from infected cells of most primary HIV-1 isolates.

Scientists have developed a new assay to accurately and easily count the cells that comprise the HIV reservoir, the stubborn obstacle to an HIV cure. This advance will enable researchers who are ...

Viruses insert their genomes into their hosts in the form of a provirus. There are around 30 different kinds of human endogenous retroviruses in people today, amounting to over 60,000 proviruses in ...

The human ERV-K exists in the provirus form in the human genome, comprising sequences encoding proteins critical for the reactivation, and RVLP (retrovirus-like particle) formation, having ...

Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nature Biotechnology 2016 Feb 22, advance online publication. doi: 10.1038/nbt.3467.