In biology, the binding of cellular proteins to molecules called ligands produces myriad functions essential for life, ...

Zhuoran Qiao has been awarded the inaugural Chen Institute and Science Prize for Al Accelerated Research for work critical to ...

Proteins are the foundation of all life we currently know. With their virtually limitless diversity, they can perform a broad ...

To develop a covalent modifier for the amyloid-forming protein β-2-microglobulin (magenta), researchers used a nanobody (teal ...

Different proteins bind better to different ligands. Once hooked, Dam’s lab uses a centrifuge to bring the protein-ligand complex down in solution and then separates the protein from the ligand, ...

Fit-ligand is a computational algorithm that enables accurate modeling of multiple conformational states of ligands in X-ray crystallography and cryo-electron microscopy (cryo-EM).

Proteins have specific biological functions in cells through conformational changes and interactions. Therefore, precise, in ...

The study, “ProteinReDiff: Complex-based ligand-binding proteins redesign by equivariant diffusion-based generative models,” is published in the journal Structural Dynamics, as part of a special topic ...