RNA cleavage can occur either: (i) by a transesterification mechanism that yields 2’,3’-cyclic-PO ... an RNA 3’-OH on the RNA–adenylate to seal the two ends via a phosphodiester bond and release AMP.

To directly visualize and characterize the mechanism of bond cleavage exhibited by I-PpoI, its structure has been determined as three distinct species on the reaction pathway, using intermediate ...

My scientific interests center on nucleases, a functionally diverse class of enzymes that catalyze the cleavage of phosphodiester bonds to support a wide breadth ... our cells support elegant ...

Traits as diverse as the color of a person's eyes and the scent of a rose are determined by the information contained in DNA. Learn how this information is coded by strings of molecules called ...