Other scientists have only recently identified hot and cold nerve cell receptors in the peripheral nervous system located just beneath the skin. This is the system that tells the brain to pull the ...

Given their localization on predominantly nociceptive afferents, we investigated whether these receptors modulate nociceptive signaling, and found that agonist-induced activation of peripheral ...

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UB researchers have uncovered how heat causes a critical receptor protein within cells to unfold and relay pain.

Endocannabinoids are lipid mediators that interact with G protein-coupled receptors, including cannabinoid CB2 receptor (CB2R), which is mainly expressed in peripheral tissues with immune functions.

Pherines specifically and selectively bind to peripheral receptors in human nasal chemosensory neurons, which activate olfactory bulb-to-brain neurocircuits without requiring systemic absorption ...