Probes are an important subsegment in the market for synthesized oligonucleotides. The segment accounted for the second-largest market share of the synthesized oligonucelotide market. This is due ...

Oligonucleotides can be used as probes to detect specific DNA or RNA sequences through hybridization. These probes are often labeled with fluorescent dyes or other reporter molecules for detection.

An oligonucleotide probe, specific for one allele, is hybridized to the target at low temperature. This forms a duplex DNA region that interacts with a double strand–specific intercalating dye.

In one approach towards this goal, we aimed to synthesize an oligonucleotide probe that we had designed for a DNA screening experiment. This synthesis involved individually adding nucleotides to a ...

Rolling-circle amplification (RCA) driven by DNA polymerase can replicate circularized oligonucleotide probes with either linear or geometric kinetics under isothermal conditions. In the presence ...

oligonucleotides containing one mismatch in their sequence are used to correct for background hybridization. An array containing 25,000 probes can provide information on the expression of all ...