That's never happened in NFL history before. In Week 4, the title of biggest underdog falls to the Patriots yet again, taking on the San Francisco 49ers. Both teams have a 1-2 record, and San ...

Tracking how lines move throughout an NFL ... 0-4 ATS in its last four games dating back to last season. Cleveland Browns at ...

A Super Bowl LV rematch in prime time highlights the slate. A topsy-turvy weekend leaves a lot of uncertainty heading into Week 4 of the NFL season. Only five teams — the 3-0 Eagles and ...

Each week on ESPN.com, the braintrust of Bristol University will convene and offer their predictions for the upcoming slate of NFL games. Here are the ESPN experts' picks for Week 4: (Editor's ...