The Burnham team, led by Dorit Hanein, Ph.D., was the first to reveal the 3D representation of myosin V "walking" along actin filament, a key protein involved in motility and muscle contraction.

Conformational changes within myosin lead to its movement relative to an actin filament. Several crystal structures exist for myosin bound to various nucleotides, but none with bound actin.

This study explores the use of polarized second-harmonic generation (pSHG) to investigate myosin conformation in the relaxed state, differentiating between the actin-available, disordered (ON) state ...

Myosin V has two "legs" connected to a "body," but exactly how the protein molecule moves its load along helical fibers of actin has been a mystery. "Studies have suggested two main models for ...

With intensifying global warming and climate change, drought has become a major threat to global agriculture, impacting crop ...

While their functions are diverse, myosins are similar in structure. NMII is so much like cardiac myosin, which keeps the ...

Over the last several years the identification and functional characterization of the motor proteins actin and myosin in the nucleus has initiated a change in the view of nuclear processes. It is now ...

However, boron is often scarce in soil, particularly in arid regions, making passive absorption impossible. To combat this, plants have evolved proteins that actively transport boron from the soil ...

The experimental image shows two proteins -- myosin (cyan) and actin (red) -- in a chick embryo during gastrulation, highlighting the main body axes and the dominant force-generating regions (cyan).

The biochemical assays were made using bovine cardiac myosin S1 and rabbit skeletal F-actin. These test compounds were mixed separately with an enzyme mixture of lactate dehydrogenase, bovine ...

The novel cardiac myosin inhibitor aficamten improved peak oxygen uptake in symptomatic obstructive hypertrophic cardiomyopathy (HCM), the pivotal SEQUOIA-HCM trial showed. At 24 weeks, the mean ...