After five years of work, a team from National Biosciences Laboratory (LNBio), in the city of Campinas, has defined the three-dimensional structure of what is called the functional, or active, region ...

The structure of myosin I bound to actin filament with tropomyosin in the rigour complex solved by a recent cryoEM study (PDB: 4A7F) 19 somehow showed the positions of Switch-1 and Switch-2 quite ...

image: This graphic shows the proposed binding site for omecamtiv mecarbil to cardiac myosin S1. The ribbon diagram to the left shows the major features of the myosin S1 head. A spacefilling model ...