Researchers have discovered that cancer cells suppress 'poison exons' -- genetic elements that act as an off switch for protein production -- in a key gene called TRA2 , promoting tumor growth. By ...

Anczuków, Leclair, and Brugiolo then went on to see if they could increase the inclusion of the poison exon in the TRA2β gene and reactivate the kill switch. They found their answer in antisense ...

They engineered a strain of M. tuberculosis carrying a triple kill switch, which uses three independent molecular mechanisms to kill the bacteria. Even in severely immunocompromised mice ...

Molecular switches are nanoscale devices that can reversibly change their state or conformation in response to external stimuli. These switches are typically individual molecules or molecular ...

Anczuków, Leclair, and Brugiolo then went on to see if they could increase the inclusion of the poison exon in the TRA2β gene and reactivate the kill switch. They found their answer in antisense ...

The discovery could pave the way for a groundbreaking RNA-based multi-cancer treatment. Alternative RNA splicing functions ...