DNA methylation, a form of epigenetic modification, involves the addition of a methyl group to the cytosine bases of the DNA, altering its accessibility in chromatin and modulating gene expression.

Why normal cells turn into cancer cells One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation (*1). The joint research groups of The ...

The research team decided to investigate the mechanism of faithful "DNA methylation inheritance" which is critical for cancer suppression and has not been sufficiently investigated.

Van Andel Institute scientists have developed an improved technique to comprehensively profile DNA methylation in single ...

DNA methylation is known to be catalyzed by DNA methyltransferases (DNMTs), but the mechanisms of demethylation are less clear. Some have proposed that demethylation takes advantage of mechanisms that ...

Overall, the team's findings thus suggest that DNA methylation is a crucial mechanism mediating the influence of early life experiences on mental health outcomes in early adolescence.

More information: Xianwei Song et al, Inheritance of acquired adaptive cold tolerance in rice through DNA methylation, Cell (2025). DOI: 10.1016/j.cell.2025.04.036 ...