Mice that lack lymph nodes due to a genetic mutation (alymphoplasia) are severely immuno-compromised and struggle in fighting infections and tumors. New work by Melanie Greter, Janin Hofmann and ...

The new paper shows that in the mouse T cell function is unperturbed in the absence of lymph nodes, whereas B cell activation and antibody secretion is strongly affected.

In lymph nodes, the PLVAP protein is like the metal sieve of a strainer, perforated with tiny holes," explains Senior Researcher Pia Rantakari, PhD, one of the key investigators behind the research.

The model functions like a lymph node-on-a-chip, recreating aspects of the human lymph node environment—including fluid flow and cellular interactions—to study immune behavior outside the body.

The lymph node (LN) is a pea-sized (0.1–2.5 cm long), bean-shaped organ of the lymphatic and immune system. A human possesses approximately 500–600 lymph nodes and collectively, lymph nodes ...

The popliteal lymph nodes are behind the knee. Conditions such as infections and autoimmune conditions can cause swelling, but it is rarely due to cancer. Learn more.

The deep inguinal lymph nodes are located below the cribriform fascia — connective tissue of the upper, inner thigh — and on the medial (closer to the body’s midline) side of the femoral vein.

"Expanding a lymph node, boosting a vaccine." ScienceDaily. ScienceDaily, 6 May 2024. <www.sciencedaily.com / releases / 2024 / 05 / 240506131555.htm>.

Reference Apollonio B, Spada F, Petrov N, et al. Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma. J Clin Invest.