Twenty-two percent of children with juvenile localized scleroderma have extracutaneous manifestations, and nearly half of those cases have joint involvement. (Zulian F et al. 2005; 52:2873-2881.) ...

Scleroderma is a rare, autoimmune condition in which the body produces too much collagen, causing the skin and connective tissue to thicken. Medical News Today Health Conditions ...

A parent is concerned because her 9-year-old daughter has been diagnosed with "localized scleroderma," after years of seeing physicians and not getting a diagnosis. A dermatologist told her to do ...

If other organs are affected you have systemic scleroderma. With localized disease, your scleroderma symptoms may include: Swelling, stiffness, or pain in the fingers, toes, hands, feet, or face; ...

Fibrocell Science announced in a press release that it has received orphan drug designation from the FDA for its FCX-013 gene-therapy candidate to treat localized scleroderma. FCX-013, an ...

Fibrocell Science has submitted an Investigational New Drug Application (IND) with the FDA for a gene therapy candidate to treat moderate to severe localized scleroderma.

Weibel L et al. (2007) Laser Doppler flowmetry for assessing localized scleroderma in children. Arthritis Rheum 56: 3489–3495 ...