Cysteinyl leukotrienes (CysLTs) are potent bronchoconstrictors, playing pivotal roles in inflammatory diseases. These lipid ...

In its most general use, "ligand" is a term for something that binds to a receptor. Often, ligands are made of proteins, like their receptors, and the binding connection between the two will cause ...

In contrast, TLRs 3, 7, 8, and 9 are situated in the membranes of endosomes and lysosomes; the extracellular domain of the receptor and its ligand-binding site project into the interior of these ...

Scott et al, Impact of Intracellular Proteins on μ-Opioid Receptor Structure and Ligand Binding, The Journal of Physical Chemistry B (2024). DOI: 10.1021/acs.jpcb.4c05214 ...

The Laboratory also provides training, such as on the use of radio-ligand receptor binding assays, a specific analytical procedure to identify harmful algal blooms. As the ocean takes up about one ...

Mapping an antibody’s epitope, where it binds a target, can now be done in three dimensions, which optimizes the selection of application-specific antibodies.

Proteins are life's engines, powering processes like muscle movement, vision, and chemical reactions. Their environments—water, lipid membranes, or other condensed phases—are critical to their ...