Innate immune responses have been shown to contribute to the control of malaria infections in mice and there is indirect evidence that they also contribute to the control of infection in humans.

Feb. 28, 2022 — The innate immune system plays a crucial role in regulating host-microbe interactions, and especially in providing protection against pathogens that invade the mucosa. Using an ...

Currently licensed and approved malaria subunit vaccines provide modest, short-lived protection against malaria. Immunization with live-attenuated Plasmodium falciparum malaria parasites is an alte ...

Now, a new study identifies a novel DNA-sensing mechanism that plays a role in the innate immune response to the parasite that causes malaria. The findings, published online Aug. 4 by Cell Press ...

Once the parasite matures and is released from the liver into the bloodstream, Plasmodium falciparum displays RH5 and infects red blood cells, which causes disease.

Researchers at Weill Cornell Medicine have discovered how Plasmodium falciparum, the parasite that causes malaria when transmitted through a mosquito bite, can hide from the body’s immune system ...

To create their experimental vaccine, the researchers deleted three genes in the pathogen that causes malaria, Plasmodium falciparum. These genes are critical to the parasites' ability to ...

An experimental malaria vaccine appears safe and promotes an immune response in African infants, one of the groups most vulnerable to severe malaria disease. There is currently only one malaria ...

The innate immune response, as outlined above, relies on cellular receptors to detect foreign materials within cells. One of these receptors, RIG-I, binds to RNA-based PAMPs and activates the ...