The tolerogenic properties of the liver make it an attractive site for infection by pathogens. This Review describes how most pathogens are effectively controlled by immune responses in the liver ...

Now, a new study identifies a novel DNA-sensing mechanism that plays a role in the innate immune response to the parasite that causes malaria. The findings, published online Aug. 4 by Cell Press ...

Once the parasite matures and is released from the liver into the bloodstream, Plasmodium falciparum displays RH5 and infects red blood cells, which causes disease.

Feb. 28, 2022 — The innate immune system plays a crucial role in regulating host-microbe interactions, and especially in providing protection against pathogens that invade the mucosa. Using an ...

The immune system is typically categorized into the innate and adaptive immune response systems, both of which are essential components in the body’s defense against pathogens. Innate versus ...

Researchers at Weill Cornell Medicine have discovered how Plasmodium falciparum, the parasite that causes malaria when transmitted through a mosquito bite, can hide from the body’s immune system ...

An experimental malaria vaccine appears safe and promotes an immune response in African infants, one of the groups most vulnerable to severe malaria disease. There is currently only one malaria ...

The innate immune response, as outlined above, relies on cellular receptors to detect foreign materials within cells. One of these receptors, RIG-I, binds to RNA-based PAMPs and activates the ...

More information: Francesca Florini et al, scRNA-seq reveals transcriptional plasticity of var gene expression in Plasmodium falciparum for host immune avoidance, Nature Microbiology (2025). DOI ...

To create their experimental vaccine, the researchers deleted three genes in the pathogen that causes malaria, Plasmodium falciparum. These genes are critical to the parasites' ability to ...