This distinct structure was first observed in 1989 during the analysis of both total and fractionated IgG from camel serum. These antibodies possess a unique antigen-binding site consisting of a ...

Over 30 years ago, receptors for the Fc region of IgG (FcγR) were implicated in the pathogenesis of systemic lupus erythematosus (SLE). Since those pioneering studies, our knowledge of the ...

IgG is the type of immunoglobulin most commonly found within human serum and can be broken down into four sub-classes: IgG1, IgG2, ... Structure and Function of Immunoglobulins; ...

Human IgA structure. Schematic diagrams of a, IgA1; b, IgA2; d, dimeric IgA1; e, secretory IgA1; and f, polymeric immunoglobulin receptor.IgA heavy-chain domains are shown in pink, light-chain ...

Although all IgG subclasses (1–4) are found in the fetal serum, transport of IgG1 is predominant. The transport capacity of IgG1–4 is in the following sequence: IgG1> IgG4> IgG3> IgG2.