Histone deacetylases (HDACs) are a class of epigenetic enzymes that remove acetyl groups from lysine residues on histones and other proteins. In this Review, the authors highlight the role of ...

Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, ...

A recent study has revealed promising targets for treating childhood acute myeloid leukaemia (AML) driven by NUP98 fusion ...

For example, if a histone protein has 10 modification sites, bottom-up proteomics can tell you that those modifications exist but not whether all 10 are on the same histone at the same time.

A recent review by Prof. Zhu Bing and Associate Professor Xiong Jun from the Institute of Biophysics of the Chinese Academy ...

During therapy, some cancer cells evolve to escape elimination. Newer anticancer drugs that can overcome this resistance are ...

Histone mutational landscape of human cancers Date: March 1, 2021 Source: Princeton University Summary: Researchers have completed a comprehensive analysis of cancer-associated histone mutations ...

Histone modification is an epigenetic mechanism that regulates gene expression by altering chromatin structure and DNA accessibility for transcription. Histone modification is regulated by various ...

So-called histone methyltransferases "also methylate a broad range of other protein substrates," Coonrod explains, noting that arginine methylation is a particularly widespread modification.

Fruit ripening determines shelf life and consumer appeal, yet the molecular switches that control this process remain ...

Histone phosphorylation at H2A on T120 and H3 at S10 are required for the compaction of chromatin and regulation of its structure and function during mitosis. Histone Modification Play.

Histone methyltransferase SETDB1 safeguards mouse fetal hematopoiesis by suppressing activation of cryptic enhancers. Proceedings of the National Academy of Sciences , 2024; 121 (52) DOI: 10.1073 ...