In a bid to better understand how cancer cells power their explosive growth and spread, scientists at Johns Hopkins Medicine ...

Glycolysis takes place in the cytoplasm. Within the mitochondrion, the citric acid cycle occurs in the mitochondrial matrix, and oxidative metabolism occurs at the internal folded mitochondrial ...

More information: Haihua Zhang et al, ING5 inhibits aerobic glycolysis of lung cancer cells by promoting TIE1-mediated phosphorylation of pyruvate dehydrogenase kinase 1 at Y163, Frontiers of ...

Cells normally make most of their energy via oxidative phosphorylation, but they need oxygen to do so. If oxygen runs short, most cells switch to aerobic glycolysis.

Aerobic glycolysis is critical for tumor growth and metastasis. Previously, we have found that the overexpression of the inhibitor of growth 5 (ING5) inhibits lung cancer aggressiveness and ...

A laboratory study demonstrates how a new targeted drug, Elesclomol, blocks oxidative phosphorylation, which appears to play essential role in melanoma that has not been well understood.

Cancer cells are capable of rapidly adapting their metabolism to thrive in challenging environments. This metabolic reprogramming provides the energy needed for tumor growth and is a key area for ...

“Accordingly, a substantially different metabolic profile at the level of glycolysis, oxidative phosphorylation, and glutamine metabolism is present in PAH-ECs compared to CTEPH-ECs and suggests ...

Harrington’s study, “Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells,” was recently published in the journal Cell Reports. Harrington ...