Prostaglandin E2 (PGE2), a bioactive lipid derived from arachidonic acid, mediates a broad range of physiological processes through four G protein-coupled receptor (GPCR) subtypes: EP1–EP4 ...

The researchers used cryo-electron microscopy (cryo-EM) to determine the structure of the human EP1 receptor in complex with PGE2 and the heterotrimeric Gq protein, completing the structural ...

Neuromodulators that activate Gq-coupled receptors exert powerful control over brain function. Here, the authors develop a fluorescence lifetime sensor capable of imaging protein kinase C activity ...

Besides, it was found that GnRH binding triggered conformational changes: the receptor's N-terminus flips outward, and TM6 shifts to form the Gq binding interface.

Neuromodulators that activate Gq-coupled receptors exert powerful control over brain function. Here, the authors develop a fluorescence lifetime sensor capable of imaging protein kinase C activity ...