G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...

These molecules are key players in health and disease. One such molecular switch is G protein-coupled receptor kinases, or GRKs for short. Their involvement in a broad range of diseases makes GRKs ...

Henderson recalls that a colleague suggested he “move away from this boring bacterial protein ... the structure of G-proteins coupled to their receptors,” he says. As well as the leap ...

A recent study published in Engineering delves into the complex mechanisms of drug addiction, highlighting the crucial role of astrocytic G protein-coupled receptors (GPCRs). This research offers ...

The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...

TAS2R14s are members of the G protein-coupled receptor (GPCR ... they found that the TAS2R14 protein in complex with the GI ...