Nature4y
The relationships of G proteins to the plasma membrane
In this diagram of G-protein-coupled receptor activation, the alpha, beta, and gamma subunits are shown with distinct relationships to the plasma membrane. After exchange of GDP with GTP on the ...
Nature6d
G protein-coupled receptors articles from across Nature Portfolio
G protein-coupled receptors (GPCRs) are integral membrane proteins with seven membrane-spanning helices. Upon binding to a ligand – which can range from small molecules like cyclic AMP to ...
Phys.org24d
Studying structure of G protein-coupled receptor kinases could improve an array of drugs
These molecules are key players in health and disease. One such molecular switch is G protein-coupled receptor kinases, or GRKs for short. Their involvement in a broad range of diseases makes GRKs ...
Royal Society of Chemistry4y
Nobel Prize for Chemistry awarded for G-protein-coupled receptors
The 2012 Nobel Prize for Chemistry has been awarded to Robert Lefkowitz and Brian Kobilka for groundbreaking discoveries that reveal the inner workings of G-protein-coupled receptors. Professor David ...