It is crucial to the very process that enables the chambers of the heart to contract and relax, a process called excitation–contraction coupling. It is important to understand in quantitative ...

In the cells of the cardiac muscle, calcium ions play a crucial role in coupling excitation and contraction. It is thus one of the most important second messengers since it regulates calcium ...

Excitation–contraction (EC) coupling is responsible for transducing the shift in the membrane voltage to increase cytosolic levels of Ca 2+ that leads to contraction. Genetic defects in EC ...