As an example, they considered the enzymatic reaction of breaking a dimer into two monomer molecules. Considering the geometry of such an enzyme-substrate-complex, they identified three golden ...

Research on γ-secretase reveals its unique substrate recognition mechanism, offering potential for developing precise therapeutic agents for various diseases.

"Scientists crack structure of enzyme complex linked to cancer." ScienceDaily. ScienceDaily, 7 February 2018. <www.sciencedaily.com / releases / 2018 / 02 / 180207140404.htm>.

Enzyme-catalysed reactions require the specific interaction between the enzyme and its substrate in the Michaelis complex. Due to turnover, Michaelis complexes are typically transient making them ...

High-resolution cryo-electron microscopy makes it possible to study complex enzymatic processes in detail. With this method, ...

Yong Xiang, Khanita Karaveg, Kelley W. Moremena, Substrate recognition and catalysis by GH47 α-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway, Proceedings of ...

They investigated a multi-enzyme complex that plays an essential role in metabolism and has discovered that it functions differently than previously thought. This will help scientists better ...