Imaging of enzyme activity is mainly carried out with fluorescence probes. However, fluorescent light barely penetrates tissues, so larger samples like whole organs cannot be mapped in 3D.

Understanding enzymes better could be a key way of devising effective drug designs for various ailments and researchers have now completed a 3D map of an enzyme called Proline utilization A (PutA).

In a recent study by the team, they discovered the 3D structure of a protein called TnpB, a probable precursor to the CRISPR-Cas12 enzyme. Their findings appeared in the journal Nature.

Gamers succeed where scientists fail: Molecular structure of retrovirus enzyme solved, doors open to new AIDS drug design Date: September 19, 2011 Source: University of Washington Summary: Online ...

Novozymes’ system creates 3D computerised models of enzymes sourced from nature to help researchers identify ways in which they could be optimised for different functions. “What takes thousands of ...

of Biochemistry has been able to take 3D images of part of a crucial medicine-synthesizing protein in action. Sending a tiny film crew to capture the molecular actions of enzymes in motion would ...