They also observed a loss of normal interactions between epithelial and stromal cells, consistent with the profibrotic nature of this syndrome. Simón and his team then created and profiled endometrial ...

As a proof-of-concept, they then used this model to show how the hormone-dependent behaviors of the endometrial epithelium in co-culture with stroma are different from those in monoculture.

Endometrial cancer—in which tumors develop in the inner lining of the uterus—is the most prevalent gynecological cancer in ...

The schematic illustration of their proposed clonal selection and diversification in normal endometrial epithelium is shown in Figure 1, where each color represents an expanding clone.

Then they cultured endometrial stromal and epithelial organoids from human donors together in the synthetic matrix, and the co-culture remained intact over the experiment period of at least 15 days.

Initial cultures of epithelial and stromal endometrial cells from human donors in the hydrogel remained intact for 15 days, outperforming those grown in Matrigel, which had begun disintegrating by the ...

After obtaining the endometrial samples, they purified single-cell suspensions of epithelial and stromal cells that were cultured in very low amounts. They found that a small number of these cells ...

Women with polycystic ovary syndrome (PCOS) find it harder to get pregnant, have more frequent miscarriages and have a higher risk of developing endometrial cancer. Now, in a new study, "Single ...

The device was used for the first time to culture two maternal endometrial ... The group discovered that high levels of glucose altered 21 protein-encoding genes in epithelial cells and 191 ...

The mutational landscape of normal human endometrial epithelium. Nature, 2020; DOI: 10.1038/s41586-020-2214-z ...