The newly synthesized DNA (light blue) can then be joined with the 5' end of the resected strand, forming a double Holliday junction (double-strand break repair; DSBR), or can be displaced and ...

DNA ligase IV is a 911-amino acid polypeptide that plays a role in the repair of double-strand DNA breaks via non-homologous end joining (NHEJ). Yeast cells contain 2 separately encoded DNA ligases, ...

A double-strand DNA break (DSB ... Cohesin plays a crucial role in both chromosome organization and DNA repair. Here the authors find that cohesin mediated genome architecture prevents ...

Homologous recombination plays essential roles in the repair of DNA double strand breaks (DSBs) and collapsed replication forks. The fundamental reaction in homologous recombination is the exchange of ...

More information: Wei Wu et al, VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair, Science ...

Single-strand breaks generated during DNA repair were observed converting to double-strand breaks and reversibly switching between states in response to oxidation in cultured neurons as well as in ...

The tethered DNA strand was comprised of a double-stranded (dsDNA ... whether the enzymatic period was during exonuclease repair or DNA extension. “This experiment is really the nail in the coffin of ...

The CRISPR-Cas9 tool appeared to activate a DNA repair pathway governed by p53, a protein known as the “guardian of the genome.” 7 This was expected for an editing tool that deliberately generates ...

The Arnoult lab focuses on genome stability, DNA repair and telomere biology. We study the different types of pathways that cells use to repair DNA double strand breaks, and how telomeres escape these ...

cells have evolved various DNA repair mechanisms. These mechanisms can detect and correct different types of DNA damage, such as base mismatches, single-strand breaks, and double-strand breaks. DNA ...