Your DNA is continually damaged by sources both inside and outside your body. One especially severe form of damage called a ...

The newly synthesized DNA (light blue) can then be joined with the 5' end of the resected strand, forming a double Holliday junction (double-strand break repair; DSBR), or can be displaced and ...

A new research paper was published in Aging's Volume 15, Issue 19, entitled, “Reduction of double-strand DNA break repair exacerbates vascular aging.” ...

A new study published in Aging Cell reveals that a well-known enzyme, long known for its involvement with cancer, actually steps into the nucleus to help repair DNA. This enzyme is Protein Disulphide ...

Studies in the field of DNA repair usually tend to look at simpler versions of double-strand breaks, he said. Dr. Daley found that each resection enzyme is tailored to deal with a specific type of ...

Recent efforts in our lab have focused on complexes mediating DNA double strand break (DSB) repair. These range from the Structure Maintenance of Chromosome Smc5/6 complex involved in rescue of ...

DNA damage has been associated with aging and disease. Double-strand breaks are one of the worst forms of damage. New research shines a light on the repair process.

More information: Wei Wu et al, VGLL3 modulates chemosensitivity through promoting DNA double-strand break repair, Science Advances (2024). DOI: 10.1126/sciadv.adr2643 Journal information: Science ...

High-resolution cryo-electron microscopy has revealed the structural mechanism by which human RAD51 mediates strand exchange during homologous recombination, a key DNA repair pathway.

Furthermore, these damages to the double-stranded DNA and nuclear envelope were followed by TLR9 signaling activation, a resulting inflammatory response, and the accumulation of centrosomal ...

Reference: Clarke TL, Cho HM, Ceppi I, et al. ZNF280A links DNA double-strand break repair to human 22q11.2 distal deletion syndrome. Nat Cell Biol. 2025;27(6):1006-1020. doi: 10.1038/s41556-025-01674 ...