DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

Cells primarily repair double-strand breaks by either rejoining the broken DNA ends or by using another DNA molecule as a template for repair. However, my team and I discovered that RNA, a type of ...

How does a cell know when it’s been damaged? A molecular alarm, set off by mutated RNA and colliding ribosomes, signals ...

Cells use a step-by-step process to untie knots in DNA, called G4 structures. First, the G4 knot is recognized as a problem by the cell. Special DNA damage response proteins start the repair by ...

Even after this treatment gained FDA approval for cell-based gene therapies for the treatment of sickle cell disease in 2023, there remain many barriers to commercial access. However, when it delivers ...

In 1978 researchers developed a DNA-based diagnostic for sickle cell. In 1984 a child with leukemia—who also had sickle cell—was given a bone marrow and blood transplant.

Innovations in cell-free gene synthesis decrease turnaround times for obtaining full-length, complex, NGS-verified DNA from weeks or months to as few as 6-8 business days. Cell-free DNA speeds ...

In 2024, new studies have exposed additional layers of this story, showing, for example, that along with bacteria and eukaryotic cells, archaea also exchange vesicle-bound RNA, which confirms that the ...

Finally, in 2018, an answer came. The anemia and medical history prompted an obstetrician to order a blood test for sickle cell disease during Sanodiya’s first pregnancy checkup.

Sunburn has traditionally been attributed to UV-induced DNA damage. However, a new study reveals that RNA, another vital cellular molecule, plays a major role in triggering acute sunburn reactions.

Additionally, we found that RNA aids in double-strand break repair in both yeast and human cells, suggesting that its role in DNA repair is evolutionary conserved across species.