DNA methylation and histone modification influence each other during development. Histone methylation can help to direct DNA methylation patterns, and DNA methylation seems to serve as a template ...

A study links the loss of DNA methylation across the genome—as is common in cancer—to the disruption of the 3-D compartments that organize the genome and to the timing of DNA replication.

The accurate distribution of chromosomes in an oocyte is essential for the correct transmission of genetic information to the ...

A new review published in Genes & Diseases explores the intricate epigenetic regulatory network of long noncoding RNAs ...

Mol. Cell 82, 1186-1198. Crosstalk Between Histone and DNA Marks Both histone modification and DNA methylation contribute to the establishment of patterns of gene repression during development, ...

Histones are proteins that condense and package DNA neatly into chromosomes. Modifications to these ... the development of HAT-targeted drugs. Histone methylation is the transfer from S-adenosyl ...

It's widely accepted that molecular mechanisms mediating epigenetics include DNA methylation and histone modifications, but a team from Thomas Jefferson University has evidence to the contrary ...

Aging involves complex cellular and molecular changes, including epigenetic modifications like Deoxyribonucleic acid (DNA) methylation and histone marks. Age predictors, or "clocks," have been ...

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

Modification of histone tails, by acetylation, methylation or phosphorylation, affects the local chromatin structure and the transcriptional regulation of adjacent genes. Pericentric heterochromatin ...