Histone modification can also attract DNA methyltransferases to initiate cytosine methylation, which in turn can reinforce histone modification patterns conducive to silencing. Experiments in ...

In the present review, we discussed the importance of DNA methylation and histone acetylation on chromatin modifications, regulation of synaptic plasticity gene expression and memory consolidation, ...

Citation Format: Chao Lu. Interplay between histone modifications and DNA methylation in cancer [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: DNA Methylation, Clonal ...

Epigenetics regulatory mechanisms, such as DNA methylation, histone modification, chromatin remodeling, and microRNA expression, act as regulatory switches to modulate gene activity, and have been ...

Thus, histone modifications generally represent a more complex and diverse mechanism to affect gene transcription than DNA methylation. In fact, one effect of DNA methylation can be to recruit ...

They next broke up the DNA from each cell type and isolated histones that bore specific modifications ... K9 methylation. While this study supports the existence of gene regulation by a histone ...

the most established and well-researched of which are histone modifications and DNA methylation. “What's exciting about the field is that our knowledge of what actually regulates the epigenome is ...

Discover how histone modifications unlock secrets of human aging, rivaling the precision of DNA methylation in decoding biological age. In a recent study published in the journal Science Advances ...

LMU molecular biologist Gunnar Schotta decodes the epigenetic silencing of problematic retroviral gene sequences. While each cell contains the complete genetic blueprint of an organism, chemical ...

Eukaryotic DNA is wrapped around a histone octamer (H3/H4 heterotetramer and two H2A/H2B dimers) to form the nucleosome, the fundamental building block of chromatin. Histone proteins are subject to ...

This is a useful study that seeks to address the role of the TET family of DNA demethylation enzymes in pancreatic beta cell senescence in the context of type 2 diabetes (T2DM). Although the concepts ...