New research shows how cells carrying damaged DNA can sidestep cell cycle checkpoints that should prevent them from dividing in a damaged state.

The cell is equipped with a number of critical checkpoint proteins that ensure the integrity of the genome and the coordination of DNA repair and cell cycle pathways. In the February 27 Nature, three ...

The cancer drugs called PARP inhibitors have a puzzling reputation: even though they are treatment mainstays for multiple ...

This ten-fold slowdown means that synthesis of the cell's genome, which usually takes about 12 hours, would take nearly five days, greatly increasing the time cells have to repair DNA damage." ...

Researchers at the University of Oxford and Nanyang Technological University, Singapore (NTU Singapore) have uncovered the ...

More specifically, high-pORG and liver metastatic primary tumor cells can develop tolerance to ongoing replication stress by increasing cell cycle activity and DNA damage repair processes.

Researchers highlight nucleolar DNA damage response in fight against cancer Peer-Reviewed Publication University of North Carolina at Charlotte image: Shan Yan, UNC Charlotte view more ...

This is an ongoing area of study by the UB researchers with their collaborators at Roswell Park Comprehensive Cancer Center. Based on the current study, these DNA damage checkpoints may now be ...

New research reveals that triggering a cell’s DNA damage response could be a promising avenue for developing novel treatments against several rare but devastating viruses for which no antiviral ...