Centromeres are important elements of chromosomes that are responsible for the proper separation of chromosomes during cell division. This function is closely related to appropriate methylation ...

Without centromeres, cells cannot divide properly ... thereby contributing to the higher-order structure of the chromosome. Figure 3 shows one model of how CENP-A and CENP-B might interact with ...

The pairs of chromosomes that have been replicated are called sister chromatids, and they remain joined at a central point called the centromere. A large structure called the mitotic spindle also ...

Research on centromere structure yields new insights into the mechanisms of chromosome segregation errors Hubrecht Institute Journal Cell Funder European Research Council, The Netherlands ...

Focusing on the centromere—the part of each chromosome that interacts with spindle microtubules to direct segregation in mitosis or meiosis—we found that the structure’s size determines the direction ...

The researchers also found that the unique sequences and structure of centromeres were the culmination of different ...

Next, the researchers investigated the biological significance of centromere distribution and analyzed the gene expression in Arabidopsis thaliana and in the Rabl-structure mutant. The researchers ...