But checkpoints themselves often fail or are overridden after a prolonged stop of the cell cycle. If this happens in the human body, the result could be unregulated cell growth and division, which ...

The cell may pause at this point to allow time for DNA repair, if necessary. Yet another critical cell cycle checkpoint takes place mid-mitosis. This check determines whether the chromosomes in ...

During each phase, the cell undergoes a series of events that prepare it for the next phase. Cell cycle checkpoints are control mechanisms that ensure that the cell cycle proceeds in a timely and ...

Cells go through a life cycle that includes growing to the right size, being equipped to perform its functions, and finally dividing into two new cells. The cell cycle is critical because it ...

The book on ‘Cell Cycle Checkpoints and Cancer’, edited by ... are also discussed in Chapter 12, this time focusing on non-apoptotic cellular responses to anticancer agents.

This study looked at the G2/M checkpoint, a specific point in the cell cycle that determines if the cell should temporarily halt its march toward division, allowing more time for the damage to be ...

These stop the cell cycle at a checkpoint where the cell pauses to inspect its genome – G1/S – and corrects any mistakes before entering DNA synthesis. If the cell detects single-stranded breaks in ...

cause the induction of p53 protein and cell cycle disruption. This process is crucial to understand fundamental biological processes and the emergence of various diseases. Now, scientists at the ...

CDKs function to phosphorylate many different proteins which are required for passing important points in the cell cycle, called checkpoints. These checkpoints are present at the end of G1 and the ...